Incircular

Startup

Incircular B.V. is a pioneering biotechnology company based in Amsterdam, specializing in protein stabilization for therapeutic and other applications. Its multidisciplinary team—including leading structural biologists and chemists—aims to unlock the full potential of proteins by addressing instability caused by chemical, thermal, and biological stresses encountered during manufacturing and use.

At the core of Incircular’s innovation is INCYPRO, a patented, AI-suported chemical protein engineering platform. Using state-of-the-art trivalent crosslinkers, INCYPRO reinforces protein structures with minimal modification, transforming fragile proteins into robust, long-lasting tools for medicine, diagnostics, and bioprocessing. The technology has demonstrated its ability to prolong biological activity, extend half-life, reduce unfolding and aggregation, and efficiently thermostabilize proteins and protein complexes.

Incircular leverages INCYPRO internally to advance a therapeutic pipeline, with lead programs targeting oncology and autoimmune diseases. In parallel, the company offers its platform to partners seeking cutting-edge protein stabilization solutions—enabling co-development and out-licensing opportunities across the biotech and pharmaceutical sectors.