Julia Harwardt | Scientist
Merck Healthcare KGaA
Julia Harwardt is a Bench Scientist in the Antibody Discovery & Protein Engineering department at Merck KGaA. She joined the company after completing her PhD in the group of Prof. Dr. Harald Kolmar at the Technical University of Darmstadt. With a strong background in biochemistry and antibody engineering, her research currently focuses on the development of multifunctional antibody derivaties for immunological and immunoncological therapies. Focusing on innovative therapies, she is contributing to advance the company's pipeline.
Appearances:
Festival of Biologics Day 1 @ 17:10
Bifunctional antibody derivatives for immune system manipulation
Festival of Biologics Day 1 @ 17:10
Bifunctional antibody derivatives for immune system manipulation
- Generation and characterization of single-domain antibody derived bispecifics
- Mimicking the function of a cytokine by triggering agonism on its receptor
- Antibody engineering to further improve the agonism
Festival of Biologics Day 1 @ 17:30
Leveraging a toolbox approach to enhance cell line development for multi-specific molecules
In recent years, the emergence of more complex biologics has been driven by the need to address diverse disease indications. These novel molecule formats including multi- and bispecific antibody formats, present challenges for standardized cell line development platforms. To overcome these challenges, both innovative technologies and highly customizable strategies are essential for creating optimal cell lines for manufacturing. At Sartorius, we have adopted a toolbox approach and combined it with automation and predictive modeling to achieve optimal titer and product quality profile. In this talk, we will expand on how this highly adaptable framework enables us to develop optimal cell lines for multi- and bispecifics and push the boundaries of non-standard antibody formats.
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